Background: The key role of leptin is regulation of appetite and body lipid and
pregnancy is a condition associated with overeating, reduction in heating and adaptation of lipid cells, culminating in increased body fat mass. So, this study was conducted to examine the relationship between changes in pre-pregnancy BMI and leptin.Methods: This Longitudinal study was conducted on ۴۵ women in the first trimester of
pregnancy using a longitudinal approach and convenience sampling method in Tehran city in ۲۰۱۵. The mothers in terms of pre-pregnancy BMI were divided into two groups: group A (n=۲۲ with normal BMI) and group B (n=۲۳ with high BMI), with maternal serum leptin being taken in ۶-۱۲ weeks and ۱۵-۲۰ weeks of
pregnancy and measured by enzyme-linked immunosorbent assay (ELISA). The statistical data were analyzed by SPSS V.۲۱ using Kolmogorov Smirnov, independent t-test, two-sample Chi square, Mann-Whitney, Regression, Pearson and Landa tests with P.V<۰.۰۵.Results: The mean age of mothers in the present study was ۲۷.۴۷±۵.۵۵ years with a minimum age of ۱۹ and a maximum age of ۳۷ years. The mean plasma leptin of the first and second trimesters of
pregnancy was significantly higher in the high BMI group than in the normal group. The correlation showed that the first trimester leptin and changes in leptin levels of
pregnancy with pre-pregnancy BMI were significantly higher in the normal group (P=۰.۰۴ and P=۰.۰۰۳).Conclusions: BMI before and during
pregnancy can be a predictor of maternal serum leptin in
pregnancy weight gain.Background: The key role of leptin is regulation of appetite and body lipid and
pregnancy is a condition associated with overeating, reduction in heating and adaptation of lipid cells, culminating in increased body fat mass. So, this study was conducted to examine the relationship between changes in pre-pregnancy BMI and leptin. Methods: This Longitudinal study was conducted on ۴۵ women in the first trimester of
pregnancy using a longitudinal approach and convenience sampling method in Tehran city in ۲۰۱۵. The mothers in terms of pre-pregnancy BMI were divided into two groups: group A (n=۲۲ with normal BMI) and group B (n=۲۳ with high BMI), with maternal serum leptin being taken in ۶-۱۲ weeks and ۱۵-۲۰ weeks of
pregnancy and measured by enzyme-linked immunosorbent assay (ELISA). The statistical data were analyzed by SPSS V.۲۱ using Kolmogorov Smirnov, independent t-test, two-sample Chi square, Mann-Whitney, Regression, Pearson and Landa tests with P.V<۰.۰۵. Results: The mean age of mothers in the present study was ۲۷.۴۷±۵.۵۵ years with a minimum age of ۱۹ and a maximum age of ۳۷ years. The mean plasma leptin of the first and second trimesters of
pregnancy was significantly higher in the high BMI group than in the normal group. The correlation showed that the first trimester leptin and changes in leptin levels of
pregnancy with pre-pregnancy BMI were significantly higher in the normal group (P=۰.۰۴ and P=۰.۰۰۳). Conclusions: BMI before and during
pregnancy can be a predictor of maternal serum leptin in
pregnancy weight gain.