The effect of microRNAs on the regulation of HIF-۱ in various cardiovascular diseases
سال انتشار: 1402
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 48
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شناسه ملی سند علمی:
ZISTCONF02_085
تاریخ نمایه سازی: 16 بهمن 1402
چکیده مقاله:
Introduction: Nowadays, the death rate due to cardiovascular diseases is increasing all over the world,which has a lot to do with the regulation of oxygen homeostasis. Also, hypoxia-inducible factor ۱ (HIF-۱) is a critical factor in hypoxia and its physiological and pathological changes.methodology: Reliable scientific sources and sites such as Web of Sciences, PubMed, Scopus,Cochrane, google scholar were searched and studied with the keywords Hypoxia-Inducible factor ۱(HIF-۱), miRNAs, Cardiovascular diseases.Discussion: HIF-۱ is involved in cellular activities including proliferation, differentiation, and cell deathin endothelial cells (ECs) and cardiomyocytes. Like HIF-۱α, which acts as a protective factor againstvarious diseases in the cardiovascular system, the protective function of microRNAs (miRNAs) has alsobeen proven using animal models.Conclusion: The number of miRNAs identified in the regulation of gene expression responsive tohypoxia and the importance of investigating the involvement of the non-coding genome incardiovascular diseases is increasing, which shows the importance of this issue. In this study, themolecular regulation of HIF-۱ by miRNAs is considered to improve therapeutic approaches in theclinical diagnosis of cardiovascular diseases.
کلیدواژه ها:
نویسندگان
Leila Abkhooie
Assistant Professor, Department of Medical Biotechnology, Faculty of Medicine, Lorestan University ofMedical Sciences, Khorramabad, Iran.
Mostafa Moradi Sarabi
Department of Biochemistry and Genetics, School of Medicine, Lorestan University of Medical Sciences,Khorramabad, Iran