Method for treating epithelial ovarian cancer (EOC)

Ovarian cancer is the third most common malignancy among women worldwide and generally appears in advanced stages, thus having the highest mortality rate.The origin of this cancer is still unknown, but research has shown that epithelial ovarian cancer is not a single disease, but consists of a diverse group of tumors that can be classified based on different morphological characteristics. Symptoms of ovarian, fallopian tube, or peritoneum cancer include pain or swelling in the abdomen. There is a possibility of this cancer spreading to the abdominal wall, lymph nodes, lungs and liver.In epithelial ovarian cancer, ۵۰% of tumors have deleterious mutations in homologous recombination repair (HRD) genes, which include BRCA.Harmful BRCA and HRD mutations have recently emerged as predictive biomarkers for the use of PARP inhibitors in ovarian cancer. Inherited risk in BRCA۱ and BRCA۲ genes also causes ovarian cancer.Treatment methods provided so far for this Cancer is hysterectomy, salpingo-furectomy, chemotherapy as well as targeted therapy with an inhibitor.Currently, all patients with a germline or somatic BRCA mutation should receive primary maintenance therapy with a PARP inhibitor.In this cancer, surgery and systemic treatment are used in the early stages of treatment.The main treatment for this cancer is reduction of R۰ cytotherapy followed by adjuvant chemotherapy. The treatment of ovarian cancer was investigated through the CRISPR system, and through the obtained results, we identified a MYBL۲-ATAD۲ proliferative signaling axis. And we explored its potential application in the development of new therapeutic strategies, especially for high-grade serous and drug-resistant OCs.During recent research, surgery, targeted treatments such as anti-angiogenic inhibitors and polyADP-ribose polymerase and new therapeutic agents were performed And the hope is that this disease will turn from a fatal disease into a curable disease.

کلیدواژه ها:

epithelial ovarian cancer ، gene ، treatment