Investigating the Effectiveness of Making Nanocomposite Powder from Aerosil, Hydroxyapatite, and Timolol Loading in Wound Healing Caused by Pilonidal Sinus Surgery: A Randomized, Controlled, Double-blind Clinical Trial Study

Introduction: Pilonidal sinus disease is an inflammatory skin disease that is associated with a lot of pain. This inflammatory disease occurs mostly in the sacrum and involves the skin and subcutaneous tissue. One of the effective treatments for this disease is surgery, and one of the most important measures after surgery in these patients is the selection and tips related to proper dressing and wound care. Proper dressings should be able to absorb secretions and keep the temperature and humidity at a balanced level and have antibacterial properties to prevent wound infection. Hydroxyapatite is a bioceramic based on calcium and phosphate. This material has biocompatible properties, local concentration of calcium and effect on the wound healing process, and it is used as an accelerator of cell proliferation and can increase water absorption by more than ۲.۵ times. Timolol belongs to the group of non-selective b۲-adrenergic receptor antagonists and can improve the wound healing process by improving the migration of keratinocytes and increasing the settling time of neutrophils and increasing inflammatory cytokines. This study was conducted with the aim of investigating the effectiveness of making nanocomposite powder from aerosil and hydroxyapatite and loading timolol in wound healing caused by pilonidal sinus surgery in Lorestan city.Methods: In this randomized clinical trial, ۱۲۰ patients over ۱۸ years of age who underwent pilonidal sinus surgery were included. Then, in screening ۴۸ hours after surgery, they were subjected to basic clinical and laboratory evaluation. After the basic evaluation, the participants were randomized into ۲ control and intervention groups. All participants in the intervention and control groups benefited from standard care, but the intervention group also received powder nanocomposite of aerosil and hydroxyapatite and timolol loading on a daily basis. Standard care of the pilonidal sinus surgical site is traditional dressing using sterile gauze on a daily basis. The duration of the intervention and control period was ۱۲ weeks (۸۴ days). During this study, the wound healing was evaluated every week by taking a digital photo of the patients by a blinded evaluator compared to randomization, and to check the bacterial status of the wound, culture was done on day zero.Results: The average wound volume was calculated ۴۱.۹ ± ۸.۰۱ cc in the controls and ۴۲.۳۵ ± ۱۰.۸۱ in the treatment arm group. The mean of healing time was ۸.۷ ± ۱.۱۸,

کلیدواژه ها:

Pilonidal sinus ، Hydroxyapatite ، timolol