Dark Classics in Chemical Neuroscience: Comprehensive Study on the Biochemical Mechanisms and Clinical Implications of Opioid Analgesics

سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 131

فایل این مقاله در 30 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

JR_CHM-7-12_004

تاریخ نمایه سازی: 16 دی 1402

چکیده مقاله:

One of the most significant medication families of drugs utilized for intensive treatment, and acute or chronic pain are morphine, opium, and opium-like drugs. The chemical synapse is the place of the effect of drugs and neurotransmitters. Opioids exert their analgesic properties through biochemical changes at chemical synapses by stimulating opioid receptors. Opioids prevent the transmission of pain messages to higher nerve centers by releasing the inhibitory transmitters in the synapse. The problem of using these substances is addiction and severe dependence on them due to the feeling of euphoria, relaxation, and painlessness caused by the use of these substances. Many aspects of the clinical action of opiates are still unknown. Therefore, research on the novel features of these compounds is ongoing in biochemistry and pharmaceutical sciences to synthesize drugs with fewer side effects and more effectiveness. On the other hand, the gate theory is one of the most important theories in controlling pain signals and analgesic drugs. Therefore, comprehensive knowledge and study of analgesic compounds are necessary to achieve the primary goal. Aromatic NH such as in tetrazole and mitragynine, and NH resonance next to the carbonyl functional group like that in carbamates has a high potential to create opioid properties due to the potential of creating tautomeric structures.

نویسندگان

Ferydoon Khamooshi

Department of Chemistry, Faculty of Science, University of Zabol, Zabol, P.O. Box ۹۸۶۱۵-۵۳۸, Iran

Samaneh Doraji-Bonjar

Department of Laboratory Medical Sciences, School of Allied Medical Sciences, Zahedan University of Medical Sciences, Zahedan, Iran

Ayobami Sunday Akinnawo

Department of Chemistry, Faculty of Science, Ekiti State University, Ado Ekiti, P.O. Box ۳۶۲۱۰۳, Nigeria

Habib Ghaznavi

Department of Pharmacology, Zahedan University of Medical Sciences, Zahedan, Iran

Ali Reza Salimi-Khorashad

Department of Parasitology and Mycology, School of Medicine, Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

Mohammad Javad Khamooshi

Department of Computer, Faculty of Electrical and Computer Engineering, University of Sistan and Baluchestan, Zahedan, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • . Galanie S., Thodey K., Trenchard I.J., Filsinger Interrante M., ...
  • . Paweł K., Magdalena L., Structural Analogy —Direct Similarity versus ...
  • . Chakraborty S., DiBerto J.F., Faouzi A., Bernhard S.M., Gutridge ...
  • . Beaudeau J-L., Blais V., Holleran B.J., Bergeron A, Piñeyro ...
  • نمایش کامل مراجع