Effect of Honey Bee Venom on Experimental Autoimmune Encephalomyelitis (EAE) as a Model for Multiple Sclerosis (MS)
محل انتشار: مجله آرشیو رازی، دوره: 76، شماره: 6
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 49
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شناسه ملی سند علمی:
JR_ARCHRAZI-76-6_017
تاریخ نمایه سازی: 6 دی 1402
چکیده مقاله:
Experimental autoimmune encephalomyelitis (EAE) has been widely employed as a model to study multiple sclerosis (MS). Interleukin-۲۷ (IL-۲۷) inhibits Th۱۷ activity and breaks the normal activity of effector T cells which cause autoimmunity. Bee venom (BV) has been used as a form of medicine from the time of ancient Greece and China. BV and BV-derived active components might have potent therapeutic effects on refractory immunological and neurodegenerative diseases, such as MS. This study aimed to investigate the effect of Iranian honey bee venom on the progression of EAE in mice. Initially, EAE was induced in ۱۲ female C۵۷BL/۶ mice through immunization with an emulsion of myelin oligodendrocyte glycoprotein ۳۵-۵۵ (MOG۳۵-۵۵) in Complete Freund’s adjuvant (CFA), followed by administration of pertussis toxin (PTx) in phosphate buffer. Following the appearance of clinical signs, the mice were treated intraperitoneally with BV. Histopathological and immunological studies were investigated, and EAE was induced in animals within ۹-۱۴ days. Results revealed a significant reduction in IL-۲۷ levels following EAE induction in mice. However, BV-treated mice showed a significant increase in IL-۲۷, compared to controls. Histopathology results revealed that the number of inflammatory cells was reduced in the brain parenchyma following BV treatment. Based on the results obtained in the present study, BV may be a suitable candidate for the treatment of inflammatory diseases, such as MS.
کلیدواژه ها:
نویسندگان
Sh Jelodar
Department of Biology, Islamic Azad University, Science and Research Branch, Tehran, Iran
A Zare Mirakabadi
Department of Venomous Animals and Anti Venom Production, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran
Sh Oryan
Department of Biology, Kharazmi University, Tehran, Iran
L Mohammadnejad
Biology, Basic Sciences, Azad Islamic University, Sciences and Research Branch, Tehran, Iran
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