Improvement of the Immune System with Two Types of Emergency Rations in the Murine Animal Model

Introduction: The efficient rescue and preservation of refugees and disaster victims hinge on the swift delivery of cost-effective, nutritionally sound food options. It is imperative to utilize food items enriched with vital nutrients and immune system fortifiers to bolster and sustain proper immune system functionality. This study seeks to delve into the immunomodulatory impacts of two distinct types of emergency rations on the immune system, utilizing a murine animal model. Methods: For this research, we handpicked four sets of ten Balb/c strain mice, each aged between ۴ to ۶ weeks and weighing in the range of ۱۷.۸ to ۱۸.۹ grams. Two of these groups were subjected to treatment diets designated as ۱ and ۲, while the other two groups were provided with control diets numbered ۱ and ۲. These diets were administered at a rate of ۳ to ۴ grams per day over a span of ۸ weeks. Following the ۸-week dietary intervention, blood samples were collected to evaluate the levels of IL-۴, IFN-γ, IgG۱, and IgG۲. Results: The outcomes revealed that the treatment groups exhibited notably higher levels of interferon-gamma (IFN-γ) when compared to their control counterparts. Additionally, the IFN-γ/IL-۴ ratio was consistently elevated within the treatment groups as opposed to the control groups. These findings strongly support an augmentation in the Th۱/Th۲ cell ratio and a substantial enhancement in cellular immune responses within the treatment group. Moreover, within the treatment group, there was an observable increase in IgG۲ antibodies and a corresponding decrease in IgG۱ antibodies in comparison to the control group. Conclusions: In conclusion, the use of emergency rations in mice has led to an increase in cellular immune responses in both treatment groups.

کلیدواژه ها:

Emergency rations ، ELISA ، Syrian hamster ، Immune system