A comprehensive bioinformatic evaluation the NTRK family as prognostic biomarkers in breast cancer

Breast cancer (BC) is the most often prevalent and diagnosed cancer worldwide, accounting for ۱ in ۸ cancer diagnoses and a total of ۲.۳ million. In ۲۰۴۰, it is anticipated that BC would account for nearly ۳ million new cases and ۱ million mortality. The neurotrophic tyrosine receptor kinase (NTRK) genes ۱/۲/۳ respectively encode tropomyosin receptor kinases (TRK) A/B/C. Intrachromosomal rearrangements resulting in NTRK gene fusions may lead to constitutive activation of TRK proteins, which subsequently function as oncogenic drivers by activating cellular growth pathways. Fusions of the NTRK gene occur in ۰.۳% of all solid tumors; meanwhile the incidence varies by cancer type. Their frequency is more than ۹۰% in uncommon malignancies such as secretory breast carcinoma and mammary analogue secretory carcinoma of the salivary gland (MASC). The intent of this bioinformatics study was to clarify the prognostic significance of the NTRK family in BC. Material and methods: We aimed to conduct a comprehensive bioinformatics analysis elucidating the prognostic values of the NTRK families in BC. Therefore, TCGA, UALCAN, Kaplan–Meier plotter, bc-GenExMiner, cBioPortal, STRING, Enrichr, GeneMANIA, and TIMER were utilized for analysis.Results:Our bioinformatics analysis indicates that high levels of NTRK۲/۳ better association with overall survival (OS) and recurrence-free survival (RFS) in BC patients; while high levels of NTRK۱ showed applicable correlation with RFS in BC patients. Consequently, our findings indicated that NTRK۳ were notably correlated with the clinical outcomes of BC patients.Conclusion:Our findings offer a fresh perspective that might aid in the therapeutic use of NTRK as predictive biomarkers in BC.

کلیدواژه ها:

NTRK ، biomarker ، prognostic ، breast cancer