Seroprevalence of strongyloides stercoralis among cancer patients in an endemic region in Iran
محل انتشار: مجله سرطان شناسی و علوم پزشکی، دوره: 3، شماره: 1
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 137
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شناسه ملی سند علمی:
JR_JCOMS-3-1_005
تاریخ نمایه سازی: 14 آذر 1402
چکیده مقاله:
Introduction:
Strongyloides stercoralis a globally widespread human intestinal nematode. Hyperinfection mainly
appears in patients with defective immune systems . This study intended to investigate the prevalence of serum positive
Strongyloides stercoralis in cancer pat ients who have never undergone chemotherapy and those who received at least
one cycle of chemotherapy chemotherapy.
Materials and Methods: This study targeted cancer patients, referred to Rasht hospital, and assigned them to two
groups of cancer patients with no history of chemotherapy and cancer patients with at least one cycle of chemotherapy.
Patient’s demographic information, underlying diseases and chemotherapy regimen were recorded, and their serum
sample was examined
Results:
۴۱۰ patients were included in this study. the majority were female ( ۵۱/۷% ). About ۴۰ patients tested positive
for serology, out of which ۱۴ were in the chemotherapy treated group and ۲۶ in chemotherapy untreated group,
indicating that the prevalence of serum positive Strongyloides sterco ralis was significantly higher in patients with no
history of chemotherapy. Moreover, eosinophilia significantly correlated with the prevalence of seropositivity. The
chemotherapy protocol containing high doses of corticosteroids could multiply the risk of positive serology by ۱۲.۷
ti mes
Conclusion:
Before chemotherapy, in areas with a hig her prevalence of Strongyloides stercoralis, especially in high
corticosteroids protocols, it may make sense to study Strongyloides stercoralis . It becomes more vital in men and
eosinophilic patients. Since serologic testing may display false negative rat es in patients with defective immune
systems, subsequently, alternative complementary methods such as fecal larval examination and fecal PCR test are
highly suggested to be carried out along with serology.
کلیدواژه ها:
نویسندگان
Fatemeh Nejatifar
Department of Hematology and Oncology, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Sheida Dejabad
Department of Internal Medicine, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran
Maryam Shakiba
Cardiovascular Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
Sirous Gharib
Department of Hematology and Oncology, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran