Relationship between KRAS and NRAS factors with clinicopathologic findings in patients with metastatic colon cancer
محل انتشار: مجله سرطان شناسی و علوم پزشکی، دوره: 3، شماره: 1
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 137
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شناسه ملی سند علمی:
JR_JCOMS-3-1_001
تاریخ نمایه سازی: 14 آذر 1402
چکیده مقاله:
Introduction:
Colorectal cancer (CRC) is the third common cancer among human and the fourth common reason of
mortalities cau sed by cancers around the world. During recent years, EGFR related molecular pathways are known as
an important therapeutic pathway. High frequency of mutations of RAS family such as KRAS and NRAS and their
rapid incidence in colon cancer indicates their h igh potential as a biomarker for early detection detection.
Materials and Methods: In this cross sectional retrograde stu dy, patients with colorectal cancer referring to Golestan
Razi and Poursina Hospitals in Iran were evaluated during years ۲۰۰۹ ۲۰۱۸. The rates of KRAS and NRAS factors
were evaluated on paraffinized pathology samples of patients with metastatic colon cance r. Then, the correlation
between mutation in these two factors with other clinicopathological findings of patients such as age, gender, tumor
grade, location of primary lesion, time to progression (TTP), family history and presence or absence of lymphovasc ular
invasion was investigated.
Results:
There was no significant correlation observed between occurrence of NRAS and KRAS with age group,
family history and gender in the present study. But there was a significant statistical correlation between the rate of
NRAS gene incidence with location of primary lesion and tumor grade. Finally, there was found a significant
correlation between both KRAS and NRAS genes w ith TTP, so that TTP of patients reported less than patients without
mutations in both groups
Conclusion:
The present study showed that presence of both mutations in KRAS and NRAS makes the prognosis of
disease worth such a way the location of primary lesion and tumor grade are two effective factors in incidence of NRAS
gene and lymphovascular invasion is the effective factor on KRAS gene incidence. also, TTP is lower among patients
with mutations in both KRAS and NRAS genes.
کلیدواژه ها:
نویسندگان
Hamid Saeidi Saedi
GI Cancer Screening and Prevention Research Center, Department of Radiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Fatemeh Nejatifar
Department of Hematology and Oncology, Razi hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Kourosh Mojtahedi
Poursina Clinical Research Development Unit, Guilan University of Medical Science, Rasht, Iran
Moein Moghaddam Ahmadi
Poursina Clinical Research Development Unit, Guilan University of Medical Science, Rasht, Iran