The application of human Wharton's jelly mesenchymal stem cells in wound healing: A narrative review
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 97
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شناسه ملی سند علمی:
JR_JCBIOR-3-1_002
تاریخ نمایه سازی: 14 آذر 1402
چکیده مقاله:
Management and treatment of chronic wounds remain a significant problem in clinical practice. Stem cell therapies are an important and promising approach for regenerative medicine because of their self-renewal and differentiation potential. Mesenchymal stem cells (MSCs), a major cellular source for regeneration, are present in almost all tissues. The use of embryonic stem cells is morally controversial because of the need to nurture and destroy embryonic cells. Therefore, adult umbilical cord tissues are of particular importance as an alternative source of perinatal tissues. Wharton Jelly is a gelatinous connective tissue in the umbilical cord containing MSCs that can differentiate into osteogenic, adipose, chondrogenic, and other lineages. These cells do not express the MHC-II molecule and show immunomodulatory properties that make them viable for allogeneic and xenogenic transplants in cell therapy. Therefore, the umbilical cord, especially the part named Wharton's jelly, is an important and promising source of mesenchymal stem cells.
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نویسندگان
Reza Rezaee
Department of Healthcare Management, School of Management and Social Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
Javad Verdi
Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Mahsa Sadeghi
Burn and Regenerative Medicine Research Center, Guilan University of Medical Sciences, Rasht, Iran
Mehran Soleymanha
Orthopedic Research Center, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran