Simultaneous Effect of Resistance Training and Folate Nano-liposome on Dopamine Receptors in the Brain Hippocampus of Alzheimer’s Rats

Background: Alzheimer’s is progressive dementia with loss of nerve cells. Physical activity and the use of nano-pharmaceutical supplements may prevent the progression of Alzheimer’s. The aim of this study was to investigate the effects of resistance training and Folate nano-liposome on the expression of D۱ and D۲ receptors in the hippocampal tissue of Alzheimer’s rats. Methods: Thirty-three male Wistar rats at the age of eight weeks were prepared from Pasteur Institute and randomly divided into ۵ groups (healthy control, Alzheimer’s control, Alzheimer + resistance training, Alzheimer + Folate nano-liposomes, and Alzheimer + resistance training + Folate nano-liposomes). Alzheimer’s was induced, and Folate nano-liposomes were injected as a supplement. The animals were anesthetized, and the hippocampus was analyzed after the last training session. Eventually, a one-way ANOVA test was used to estimate the differences between groups (P ≤ ۰.۰۵). Results: The results of one-way ANOVA showed a significant difference between the groups in terms of D۱ mRNA and D۲ mRNA (P ≤ ۰.۰۰۰). Based on the results of the Bonferroni post hoc test, there was a significant difference between the control group and the Alzheimer’s, Alzheimer’s + resistance training, and Alzheimer’s + Folate nano-liposomes. Similarly, a significant difference was found between the Alzheimer’s group and Alzheimer’s + resistance training and Alzheimer’s + resistance training + Folate nano-liposomes (P ≤ ۰.۰۵). Conclusion: Resistance training and Folate nano-liposomes changed the content of D۱ and D۲ in the brain after Alzheimer’s induction. These changes may be partly due to the synergistic effect of physical activity and nano-pharmaceuticals on preventing or reducing the detrimental effects of pathological conditions. Inflammatory factors appear to be associated with neurotrophic factors during activity and exercise in neurodegenerative diseases.

کلیدواژه ها:

Exercise training ، Dopamine receptors ، Supplement ، Immune system