Antifungal and antibacterial activities of polyherbal toothpaste against oral pathogens, in vitro
محل انتشار: مجله قارچ شناسی پزشکی، دوره: 4، شماره: 2
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 93
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شناسه ملی سند علمی:
JR_CUMM-4-2_004
تاریخ نمایه سازی: 11 آذر 1402
چکیده مقاله:
Background and Purpose: Herbal toothpastes are more secure and efficacious and less poisonous due to containing natural chemicals as compared with the synthetic toothpastes. The present study aimed to formulate a polyherbal toothpaste using accessible medicinal plants in Iran and evaluate its efficiency in the protection of oral hygiene and prevention of dental caries. Materials and Methods: The developed toothpaste was made of the leaf extracts of Artemisia dracunculus, Satureja khuzestanica (Jamzad), and Myrtus communis (Linn), combined at four different dilutions, namely ۱:۴ (۲۵%), ۱:۱ (۵۰%), ۳:۴ (۷۵%), and (۱۰۰%), with sterile distilled water. The product was tested against five microorganisms, including Streptococcus mutans, Lactobaccilus caseie, S. sanguis, S. salivarius, and Candida albicans, using agar well diffusion method. Results: After ۲۴ h of incubation, the maximum mean diameters of inhibition zone against L. caseie and C. albicans were obtained as ۱۷-۳۰ and ۱۰-۲۵ mm, respectively. Furthermore, the minimum mean diameter of inhibition zone against S. salivarious was estimated as ۱۵-۲۰ mm. Conclusion: The formulated toothpaste showed potent inhibitory activities against Gram-positive bacteria and C. albicans. Therefore, more studies are required to accurately investigate the efficacy of the formulated toothpaste.
کلیدواژه ها:
نویسندگان
Batool Sadeghi-Nejad
۱Abadan School of Medical Sciences, Abadan, Iran
Eskandar Moghimipour
۲Medicinal Plant Research Center, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Sedigheh Yusef Naanaie
The Agricultural and Natural of Resources center, Ahvaz, Iran
Shahrzad Nezarat
Student Research Committee, Abadan School of Medical Sciences, Abadan, Iran