Synthesis and identification of cross-linked chitosan/tripolyphosphat/dacarbazinenano-composite

Various nanocarrier preparations have been designed to improve therapeutic efficacy andreduce toxic side effects. Nanocarriers prospect a continuous, direct, and controlled drug releaseto the malignant cells selectively with augmented drug localization and cellular uptake.Nanoparticles can be automated to identify malignant cells and give discriminating and precisedrug transfer, evading contact through the normal cells [۱].Nanoparticles developed from naturalpolymers like albumin, heparin and chitosan are used to create nanoparticles for the targetedtransport of nucleotide-based drugs, oligonucleotide drugs and proteins [۲]. Chitosan (CS) is themost important derivative of chitin which is prepared by the alkaline deacetylation of chitin [۳].The ionic gelation of chitosan by the addition of sodium tripolyphosphate (TPP) is used toprepare chitosan nanoparticles. TPP is a small negative ion that contains three negative chargesat physiological pH and its non-toxicity favors its medical application. This compound is able tocreate five ionic cross-linking points with cationic groups of chitosan. These characteristics makeTPP one of the best cross-linking agents for preparation of chitosan nanoparticles [۴]. In thisstudy, solution Chitosan and dacarbazine )chemotherapy medication( are mixed together in thedark, then combined with tripolyphosphate solution in a water bath. Using FT-IR, SEM-EDS,NANO DRAP, TGA-DTA and XRD techniques, the structural characteristics of the resultingcomposite, the percentage of drug use on the Pharmaceutical platform and, also the entrapmentefficiency are investigated. As a result, Dacarbazine drug with rod morphology is placed on thechitosan/tripolyphosphate nanocomposite.

کلیدواژه ها:

Chitosan ، Tripolyphosphat ، Dacarbazine