Potential electrospun Chitosan/Polyvinyl alcohol/Cyclophosphamidenanofibers for anticancer applications

Recently, electrospun polymeric nanofibers have proven to be an interesting strategy for drugdelivery systems application. The high surface-to-volume ratio of the fibers can improve someprocesses, such as, drug loading. One of the most important and studied areas of electrospinningis in the drug delivery field, for the controlled release of anticancer agents. Different drugs can beeasily incorporated into electrospun materials and their release profile can be controlled throughchanges in the fiber's morphology, porosity, and composition. Therefore, nanofibers can bepromising materials for many biomedical applications such as anticancer drugs [۱]. Chitosan (C.S)has proven challenging to electrospun. Polyvinylalcohol (PVA) is a polymer that has been studiedintensively because of its good film forming and physical properties. To improve mechanicalproperties, C.S/PVA composite by electrospun method has challenging [۲, ۳]. requirement in thefields of medicine and drug deliveryCyclophosphamide (CP) is an important anticancer drug thatbelongs to the class of alkylating agents. (CP) is mostly used in bone marrow transplantation,rheumatoid arthritis, lupus erythematosus, multiple sclerosis, neuroblastoma, and other types ofcancer [۴]. By combining the advantage of electrospun nanofibers (PVA/C.S) and CP, wesynthesize a new carrier system consisting of nanofiber (C.S/PVA/CP). The physicochemicalproperties of nanofiber were characterized by Infrared spectroscopy (IR), Scanning ElectronMicroscopy (SEM-EDX), Ultraviolet-Visible spectroscopy (UV-VIS), and X-ray diffraction.Finally, the results showed that the drug was loaded on the nanofibers in a nanoscale with aspherical morphology.

کلیدواژه ها:

Chitosan ، Polyvinyl Alcohol ، Nanofiber ، Electrospinning ، Cyclophosphamide