The effect of TPP concentration on levothyroxine release from nanoclay/chitosan nanocomposite

A nanoparticle polymer has been developed as a potential platform for drug delivery.Nanoclay/Chitosan nanocomposite was prepared with tripolyphosphate (TPP) by the ioniccrosslinking method. The particle size of Nanoclay/Chitosan nanocomposite was in the range of۱۹۰-۲۵۰ nm and encapsulation efficiencies of levothyroxine were ۸۵%. A non-invasive way todeliver drugs to the deepest parts of the human body is ultrasound. To study how ultrasound causeslevothyroxine to be released from chitosan nanoparticles, cumulative release was examined. In thisreport, we explore the effect of ultrasound on the release behavior of levothyroxine fromNanoclay/Chitosan nanocomposite. The drug release from chitosan nanoparticles was enhancedusing the ultrasound wave.

کلیدواژه ها:

Nanoclay ، Chitosan ، TPP ، Nanocomposite