Investigation of adsorption kinetics of phenobarbital on Fe۳O۴/SBA-۱۶-NH۲ nanocomposite

In traditional drug delivery systems, the drug is distributed throughout the body through thecirculatory system, and due to the distribution of the drug throughout the body, only a smallpercentage of the drug reaches the target tissues [۱,۲]. The purpose of targeted drug delivery is toincrease the drug concentration in the target tissue and decrease its concentration in other tissues[۳]. To achieve this goal, the designed systems must be such that the body's defense system is notstimulated and the carriers can stay longer in the bloodstream and reach the target tissue to agreater extent [۴]. In this study, the kinetics of phenobarbital drug absorption on Fe۳O۴/SBA-۱۶-NH۲ magnetic nanocomposite as a drug carrier was investigated. For this purpose, Fe۳O۴/SBA-۱۶-NH۲ magnetic nanocomposite was synthesized in the first step. Then, zero-order, pseudofirst-order, pseudo-second-order, and Higuchi models were investigated to find the best kineticmodel of phenobarbital drug absorption on Fe۳O۴/SBA-۱۶-NH۲ magnetic nanocomposite. Theresults showed that the loading process of phenobarbital in Fe۳O۴/SBA-۱۶-NH۲ magneticnanocomposite is consistent with the pseudo-first order model. Figure ۱ shows the synthesisstrategy of Fe۳O۴/SBA-۱۶-NH۲ nanocomposite and its application in phenobarbital drug loadingand release.

کلیدواژه ها:

Adsorption ، Response Surface Methodology ، Phenobarbital ، Fe۳O۴/SBA-۱۶-NH۲ ، Drug Delivery.