Role of Single Nucleotide Polymorphismsin miRNA and Breast Cancer Risk
- سال انتشار: 1402
- محل انتشار: اولین کنگره بین المللی ژنومیک سرطان
- کد COI اختصاصی: CGC01_300
- زبان مقاله: انگلیسی
- تعداد مشاهده: 49
نویسندگان
Master of Molecular Genetics ,Department of Molecular Genetics,Faculty of Biological Sciences, Tarbiat Modares
چکیده
Breast cancer is a heterogeneous disease, and as the most commoncancer in women, many genes are involved in it. Whilehigh penetrance genes BRCA۱ and BRCA۲ play an essentialrole in tumorigenesis, moderate and low penetrance genes arealso involved. microRNA molecules in the central dogma limitthe translation process. Any changes in their sequence, especiallysingle nucleotide polymorphisms (SNPs), may lead to anincreased risk of breast cancer. SNPs are the most common variantsin the human genome. Although the role of miRNA SNPsin BC susceptibility has been widely studied, results have beeninconsistent. miR-SNPs are considered as potential biomarkersfor the early detection of breast cancer, but their role in diseaseprogression is not well established. Therefore, more studiesare needed to understand the role of these genes in breastcarcinogenesis. In the current study – with a descriptive-reviewmethod, the investigation of important genetic polymorphismsin breast cancer, the introduction of known miR-SNPs that arerelated to breast cancer, and the relationship of polymorphismswith the risk of breast cancer have been discussed. The resultsshow that by continent, the highest proportion of studies to datehave been conducted in Asia (۶۵.۰%) and the lowest proportionin Africa (۱.۸%). SNPs rs۲۹۱۰۱۶۴ (miRNA ۱۴۶a), rs۱۱۶۱۴۹۱۳(miRNA-۱۹۶a۲), rs۳۷۴۶۴۴۴ (miRNA-۴۹۹), and rs۶۵۰۵۱۶۲(miRNA-۴۲۳) were most associated with increased BC risk.Also, the effect of an SNP on BC risk depends on the population'sraceکلیدواژه ها
single nucleotide polymorphisms, miRNA, breastcancer, association studiesمقالات مرتبط جدید
- سرطان چگونه به وجود می آید؟
- آشنایی با انواع سرطان و علائم آنها، راه های تشخیص و درمان
- Deciphering the Impact of the L۸۵۸R Mutation in EGFR: Computational Insights and Therapeutic Implications in Non-Small-Cell Lung Cancer
- systematic review on Investigating the relationship between obesity and breast cancer in women
- بررسی تغییرات بیان ژن های دخیل در بروز سرطان کارسینوم سلول های سنگفرشی دهان مطالعه متا آنالیزی
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.