Investigating the Relation between LCK Gene Expression with Type ۲ Diabetes Patients in Yazd Diabetes Research Center

Type ۲ diabetes mellitus (T۲DM) is characterized by insulin resistance and insulin secretory defect. Deficiency of cellular immunity is known as one of the factors involved in the pathogenesis of T۲DM. lymphocyte-specific protein tyrosine kinase( LCK) is an important gene involved in the intracellular signaling pathways of lymphocytes. This study aimed at determining and comparing LCK gene expression levels in diabetic patients compared with the healthy controls. Materials and Methods: In this case-control study, ۶۰ people, including ۳۰ T۲DM and ۳۰ healthy people were included. The expression levels of the LCK gene were measured by real-time polymerase chain reaction and the obtained data were analyzed by T-test in GraphPad Prism۶ software. Results: The expression level of the LCK gene was increased in diabetic samples compared with the healthy samples (P= ۰.۰۰۰۱). Conclusion: The results suggested that changes in the expression levels of LCK gene can play a role in the pathogenesis of T۲DM.

کلیدواژه ها:

Type ۲ diabetes mellitus ، LCK gene ، Gene expression