Atherosclerosis Surrogate Marker in Diabetic Patients

Objective: Duplex ultrasonography is a non-invasive, non-expensive screening test for carotid disease. Intima media thickness (IMT) is appropriate for atherosclerosis process diagnosis. Leukoaraisis (LA) increase the risk of cerebrovascular accident (CVA). LA patients need preventive medication for CVA. IMT is a non-invasive diagnostic and prognostic test in LA. The aim of this study was evaluate the carotid IMT and LA in diabetic patients as atherosclerosis surrogate marker. Materials and Methods: The case-control study was done on ۱۰۰ diabetic patients and ۱۰۰ controls. They were selected by simple sampling method in Shaheed Sadoughi MRI unit. Two groups member were matched by age and sex. The patient’s information (age, sex, weight, height, past medical history, smoking history, ischemic heart disease(IHD), CVA and past medication) according the study checklist was collected. All statistical analysis was done by SPSS۲۱. Results Totally ۲۰۰ patients were studied, ۱۰۲ in normal group and ۹۸ in diabetic group. The mean age of patients was ۶۴.۳۹ (±۹.۱۲) and ۴۷% participants were male. There were no statistical differences between hypertension and hyperlipidemia frequency in two groups (P-value>۰.۰۵). The mean of left CIMT was ۰.۸۵۶ (±۰.۲۰۲) in normal and ۰.۹۶۲ (±۱۷۱) in diabetics groups (P-value: ۰.۰۲۶). The mean of right CIMT was ۰.۸۵۳ (±۰.۲۱۵) in normal and ۰.۹۷۳ (±۱۸۸) in diabetics groups (P-value: ۰.۰۲۴). The LA was significantly more prevalent in diabetic patients (P-value:۰.۰۰۱). Conclusion: LA increases the risk of CVA and dementia. The LA pathology is unknown. The epidemiological studies revealed the age, diabetes, smoking and atherosclerosis are related with LA. Our findings showed that CIMT as an atherosclerosis marker was higher in LA patients than control group.

کلیدواژه ها:

Leukoaraisis ، Intima media thickness ، Duplex ultrasonography ، Diabetes.