Comparative Effect of Two Different Doses of Vitamin D on Diabetic Foot Ulcer and Inflammatory Indices among the Type ۲ Diabetic Patients: a Randomized Clinical Trial

Objective: The current study was conducted to compare the effect of ۱۵۰,۰۰۰ and ۳۰۰,۰۰۰ IU of vitamin D on the healing status of diabetic foot ulcer among the patients with diabetes. Materials and Methods: This randomized clinical trial was carried out on ۴۷ patients with diabetic foot ulcer and vitamin deficiency during four weeks follow-up. The patients were randomly assigned into two groups; group G۱۵۰ was administered ۱۵۰۰۰۰ IU of vitamin D and group G۳۰۰ was administered ۳۰۰۰۰۰ IU of vitamin D. Serum ۲۵-hydroxyvitamin D, ulcer area, fasting blood sugar (FBS), c-reactive protein (CRP), white blood cells (WBC) and erythrocyte sedimentation rate (ESR) were measured in both groups before and after intervention. Results: Serum vitamin D level in both groups was significantly increased compared to the baseline (P<۰.۰۱). The mean of serum vitamin D changes were ۱۲.۶±۵.۰ and ۱۸.۴±۶.۴ ng/ml (P=۰.۰۰۱) in G۱۵۰ and in G۳۰۰, respectively. The ulcer area was significantly reduced in both groups compared to the baseline (P<۰.۰۱).WBC, ESR, FBS and CRP were significantly declined compared to the baseline in both groups. However, the mean changes of serum FBS and CRP levels were found to be significantly different between groups. Discussion: The findings showed administration of ۱۵۰,۰۰۰ and ۳۰۰,۰۰۰ IU of vitamin D improved the ulcer and vitamin D status and reduced ESR, CRP, WBC and FBS in the patients with diabetic foot ulcer. In addition, the ۳۰۰,۰۰۰ IU of vitamin D was significantly more effective than ۱۵۰,۰۰۰ IU.

کلیدواژه ها:

Diabetic foot ulcer ، Vitamin D ، Fasting blood sugar ، C-reactive protein