Evaluation of the Salivary Total Antioxidant Capacity and Lipid Peroxidation Status in Type ۲ Diabetes Mellitus Patients

Objective: Type ۲ diabetes mellitus (T۲DM) is a multifactorial disorder with various disturbances in biochemical processes such as antioxidant status and lipid peroxidation. The aim of present study was evaluation of the oxidative stress markers in saliva of T۲DM patients. Materials and Methods: In this study, ۸۰ (۴۰ T۲DM and ۴۰ control) individuals were assessed. The salivary total antioxidants capacity and lipid peroxidation were determined by the ferric reducing antioxidant power (FRAP) method and Thiobarbituric acid reactant substances (TBARS) assay, respectively. Results: Total salivary antioxidants value was significantly lower in T۲DM patients compared with healthy controls (P -value: ۰.۰۱). A significant increase in lipid peroxidation was seen in T۲DM (P-value: ۰.۰۰۰۱). Conclusion: The findings of the present study suggest that diabetic patients confront a disturbed state of antioxidant defense, especially the reduction in total antioxidant capacity of body.

کلیدواژه ها:

Lipid peroxidation ، Saliva ، Total antioxidant capacity ، Type ۲ diabetes mellitus