The Effect of Aerobic Training and L- Carnitine on BCL۲ and Mitochondrial Enzymes of Rat's Kidney

سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 135

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شناسه ملی سند علمی:

JR_IJDO-11-2_010

تاریخ نمایه سازی: 16 آبان 1402

چکیده مقاله:

Objective: Diabetes causes free radical production, oxidative stress and alterations in mitochondrial enzymes and apoptosis. The purpose of this study was to investigate the effect of aerobic exercise and consumption of L-carnitine on BCL۲ and some mitochondrial enzymes of the kidney in diabetic rats. Materials and Methods: In this experimental study, ۴۵ male wistar rats (۲۰۰-۳۰۰ gr) were simple randomly divided into six groups: ۱) placebo group, ۲) healthy control group, ۳) diabetic control group, ۴) diabetic group receiving L- carnitine, ۵) diabetic group of aerobic training and ۶) diabetic group of aerobic training and recipient of L-carnitine. Rats with a serum glucose level higher than ۳۰۰ mg/ dL were considered diabetic. L-carnitine recipients received ۱۰۰ mg of L-carnitine daily orally. The dependent variables of the study were measured ۲۴ hours after the last training program session by ELISA in kidney tissue. Data were analyzed by Shapiro- Wilk and two way ANOVA and Tukey post hoc test at P-value< ۰.۰۵. Results: The results showed that the combined effect of aerobic training and supplementation of L-carnitine on Bcl۲ factor of kidney tissue of rats with diabetes has a significant effect (P-value: ۰.۰۱۹). But aerobic exercise (P-value: ۰.۹۶۹) and supplementation of L-carnitine (P-value: ۰.۵۸۴) were not significant. Conclusion: The results of this study showed that the combined effect of aerobic exercise and supplementation of L-carnitine on CPT۲ and Malonyl COa and Bcl۲ have a significant effect on the kidney of diabetic rats. Also, exercise alone and consumption of L-carnitine alone do not have a significant effect.

نویسندگان

Ali Fakourian

Department of Physical Education and Sport Scince, Islamic Azad University, Central Tehran Branch, Tehran, Iran

Homaee Hasan Matin

Department of Physical Education and Sport Scince, Islamic Azad University, Central Tehran Branch, Tehran, Iran

Mohammad Ali Azarbayjani

Department of Physical Education and Sport Scince, Islamic Azad University, Central Tehran Branch, Tehran, Iran

Parvin Farzanegi

Department of Physical Education and Sport Scince, Islamic Azad University, Sari Branch, Sari, Iran.