Biological Activity and Chemical Composition of Essential Oil ofSalvia sharifiiRech.f. &esfan.

Salvia(common name: sage), the largest genus of the Lamiaceae family, includes about ۹۰۰species.Fifty-eight species are found in Iran, among which ۱۷ are endemic [۱]. SalviasharifiiRech.f. &esfan.is an endemic plant that growing in south of Iran. Persian name for the S.sharifii is “Maryam golijonoobi” and in the southland of Iran, different preparations of this plante.g., decoctions, infusions and powders, are used as antiseptic, carminative, digestive andanalgesic [۲]. GC and GC/MS analysis of the plant essential oil resulted in the identification of۳۵ compounds representing ۹۵.۰۱% of the oil. Linalool (۳۲.۹%), hexyl isolaverate (۱۵.۴%) andHexyl ۲-methyl butanoate (۱۰.۹%) were detected as the major components consisting ۵۹.۲% ofthe oil. The essential oil showed good antioxidant activities, (IC۵۰ = ۱۶.۸ μg/ml) which correlatedwell with the total phenolic content (۰.۳۹۰± ۰.۰۰۴ mg catechin /g essential oil) of the oil (R۲:۰.۸۲۲, p < ۰.۰۰۰۱).It also inhibited the growth of all tested bacteria and fungi. The results ofantitumor activity show that this plant exhibit antitumor properties and it show enhancedinhibitory activity compared to synthetic control compounds such as cisplatin and oxaplatin