Adsorptive Stripping Square Wave Voltammetric Determination of Oxycodone by an Overoxidized Poly(۴-aminophenol) Modified Glassy Carbon Electrode
محل انتشار: دهمین سمینارملی شیمی و محیط زیست ایران
سال انتشار: 1400
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 84
متن کامل این مقاله منتشر نشده است و فقط به صورت چکیده یا چکیده مبسوط در پایگاه موجود می باشد.
توضیح: معمولا کلیه مقالاتی که کمتر از ۵ صفحه باشند در پایگاه سیویلیکا اصل مقاله (فول تکست) محسوب نمی شوند و فقط کاربران عضو بدون کسر اعتبار می توانند فایل آنها را دریافت نمایند.
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
NSCEI10_009
تاریخ نمایه سازی: 18 شهریور 1402
چکیده مقاله:
Oxycodone is an opioid medicine that is widely prescribed for the treatment of the diseases that are accompanied with sever and chronic pains. In the recent decade, residual pharmaceutical compounds (especially antibiotics and analgesics) have begun to be considered as emerging environmental pollutants due to their continuous input and persistence to aquatic ecosystem even at trace concentrations. Besides, oxycodone is very addictive and at high dosages cause serious life-threatening side effects including bradycardia, circulatory collapse, respiratory depression and even death. In this respect, developing a rapid, simple and sensitive analytical method for the determination of oxycodone is very important. Therefore, in this study, overoxidized poly(۴-aminophenol) was electrosynthesized on the surface of a glassy carbon electrode and its applicability for the measurement of oxycodone was investigated for the first time. The modified electrode was characterized by Fourier-transform infrared spectroscopy (FT-IR), cyclic voltammetry (CV) and square wave voltammetry (SWV) techniques. The obtained voltammograms showed a well-defined peak for oxycodone at +۱.۳۶ V (vs SCE). The influence of all of the effective experimental parameters on the signal intensity was investigated and optimized. Under the optimized conditions, the designed sensor exhibited two dynamic ranges (۲۰-۱۰۰ μM) and (۱۰۰-۱۰۰۰ μM) with y = ۰.۰۷۰۱x + ۵.۸۰۳۳ (R۲=۰.۹۹۸۴) and ۰.۰۱۴۶x + ۱۱.۵۱۹ (R۲=۰.۹۹۸۵) equations respectively. The values of limit of detection (LOD) and limit of quantification (LOQ) were ۵.۷۵ and ۱۹.۱۷ μM respectively.
کلیدواژه ها:
Oxycodone ، Adsorptive stripping square wave voltammetry ، Poly(۴-aminophenol) ، Electrochemical sensor
نویسندگان
M.R Jalali Sarvestani
Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran
T Madrakian
Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran
A Afkhami
Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran