Antifungal efficacy of citric and tartaric acids and their combination against Candida albicans and Malassezia furfur

The present study was to evaluate the effects of citric and tartaric acids and their combination on the growth inhibition of some important pathogenic fungi in vitro. Candida albicans and Malassezia furfur were cultured into specific media and then, yeast cells were harvested from the medium surface and counted by hemacytometer method. The antifungal susceptibility test of citric and tartaric acids and their combination against fungi were assayed by broth macrodilution technique. The results demonstrated that citric acid had more fungistatic and fungicidal activities than those of tartaric acid against pathogenic yeasts tested. Antifungal activity of the acids combination was similar to citric acid, but higher than tartaric acid alone. Further research is needed to assess the efficacy of citric and tartaric acids as inhibitors of fungal growth in clinical trials, especially in treatment of patients with yeasts infections

کلیدواژه ها:

Citric acid ، Tartaric acid ، Antifungal activity ، Candida albicans ، Malassezia furfur.