Antibacterial activity and efficient synthesis of ۳,۴ dihydropyrano [c] chromene derivatives by using ammonium trifluoroacetate (CF۳COONH۴) catalyst

سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 61

فایل این مقاله در 8 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

JR_IJMM-11-2_008

تاریخ نمایه سازی: 16 مرداد 1402

چکیده مقاله:

Background and Aim: In this research, we present a three-component method for the preparation of ۳,۴-dihydropyrano[c]chromene derivatives in the presence of ammonium trifluoroacetate. All the compounds were evaluated for their in vitro antimicrobial activity against different bacterialstrains. Antibacterial behavior of product was studied based on reference Gram-positive and Gram- negative bacteria. Materials and Methods: ۳,۴-Dihydropyrano[c]chromenes were synthesized using an efficient condensation of ۴-hydroxycoumarin, aryl aldehydes and malononitrile catalyzed by ammonium trifluoroacetate. Different concentrations of analogs and positive control drugs were prepared in DMSO. Inoculums and sterile water were added to the fourteen test tubes each containing ۱ mL of test solution at different concentrations. The tubes were incubated for ۲۴h at ۳۷ °C. After the incubation time, the antimicrobial activity was carefully evaluated. Results: In an optimized reaction condition, the products ۴a-j were obtained in high yields under reflux conditions. The antimicrobial screening data revealed that the compounds ۴b and ۴e have shown good activity against Gram-negative Escherichia spp. Conclusions: Present methodology offers several advantages such as short reaction time, simple procedure with an easy work-up and mild reaction conditions. We anticipated that the present method will receive the attention of medicinal chemists and be used for elaborate synthesis and pharmaceutical screening of chromenes based molecules.

نویسندگان

Naser Montazeri

Department of Chemistry and Medicinal Chemistry, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Biot C, Glorian G, Maciejewski LA, Brocard JS. Synthesis and ...
  • Hafez EAA, Elnagdi MH, Elagamey AGA, EL-Taweel FMAA. Nitriles in ...
  • Beagley P, Blackie MA, Chibale K, Clarkson C, Meijboom R, ...
  • Morgan LR, Jursic BS, Hooper CL, Neumann DM, Thangaraj K, ...
  • Heravi MM, Sadjadi S, Haj NM, Oskooie HA, Bamoharram FF. ...
  • Abdolmohammadi S, Balalaie S. Novel and efficient catalysts for the ...
  • Paul S, Bhattacharyya P, Das AR. One-pot synthesis of dihydropyrano[۲,۳-c]chromenes ...
  • Mehrabi H, Abusaidi H. Synthesis of biscoumarin and ۳,۴-dihydropyrano[c]chromene derivatives ...
  • Heravi MM, Zakeri M, Mohammadi N. Morpholine Catalyzed One-pot Multicomponent ...
  • Khurana JM, Nand B, Saluja P. DBU: a highly efficient ...
  • Shaker RM. Synthesis and reactions of some new ۴H-pyrano[۳,۲-c]benzopyran-۵-one derivatives ...
  • Jiang W, Xiang Z, Xu B, Li X, Liu F, ...
  • Seifi M, Sheibani H. High Surface Area MgO as a ...
  • Mohammadi Ziarani G, Badiei A, Azizi M, Zarabadi P. Synthesis ...
  • Montazeri N, Noghani T, Ghorchibeigy M, Zoghi R. Pentafluoropropionic Acid: ...
  • Patel DS, Avalani JR, Raval DK. One-pot solvent-free rapid and ...
  • Karimi AR, Sedaghatpour F. Novel Mono- and Bis(spiro-۲-amino-۴H-pyrans): Alum-Catalyzed Reaction ...
  • Khurana JM, Kumar S. Tetrabutylammonium bromide (TBAB): a neutral and ...
  • Montaghami A, Montazeri N. An efficient method for the one-pot, ...
  • Tabatabaeian K, Heidari H, Mamaghani M, Mahmoodi NO. Ru (II) ...
  • Saha M, Pal AK. Palladium (۰) Nanoparticles: A Novel and ...
  • Fotouhi L, Heravi MM, Fatehi A, Bakhtiari K. Electrogenerated base-promoted ...
  • McFarland J. The nephelometer: an instrument for estimating the number ...
  • Mallie M, Bastide JM, Blancard A, Bonnin A, Bretagne S, ...
  • Uzun O, Arikan S, Kocagöz S, Sancak B, Unal S. ...
  • Sangani CB, Mungra DC, Patel MP, Patel RG. Synthesis and ...
  • El-Saghier AM, Naili MB, Rammash BK, Saleh NA, Kreddan KM. ...
  • Mirnejad R, Vahdati AR, Rashidiani J, Erfani M, Piranfar V. ...
  • نمایش کامل مراجع