Decreased Expression Levels of S۱۰۰A۱۲ and RAGE May Be Associated with Chronic HBV Infection

Background and Aims: Engagement of the receptor for advanced glycation end products (RAGE) and its ligand “S۱۰۰A۱۲ protein” induce a cascade of reactions that eventually might lead to develop an inflammatory response dependent on NF-κB. Although involvement of S۱۰۰A۱۲ and RAGE in some autoimmune disease have proved, in chronic hepatitis B (CHB) infection functions of the proteins are not clear thus far. Determining of expression of S۱۰۰A۱۲ and RAGE in peripheral blood cells of the CHB patients was the aim of the present study. Materials and Methods: In the case-control study the mRNA levels of S۱۰۰A۱۲ and RAGE genes of the sixty CHB patients and sixty healthy donors were measured by real-time polymerase chain reaction method. The patients and healthy donors were sex and age-matched. Results: The findings demonstrated expression of S۱۰۰A۱۲ and RAGE in the CHB patients significantly decreased compared to the healthy donor group (p=۰.۰۰۱). Expression levels of the genes were not altered among HBeAg-positive and HBeAg-negative CHB patients. The HBV-DNA copy number/ml did not affect the expression of S۱۰۰A۱۲ and RAGE in the patients (p>۰.۰۵). Conclusions: The results of the study suggested that down regulation of RAGE and S۱۰۰A۱۲, because of their role in inducing inflammation, might have a considerable role in chronicity of hepatitis B.

کلیدواژه ها:

Chronic hepatitis B ، RAGE ، S۱۰۰A۱۲ ، هپاتیت B مزمن ، S۱۰۰A۱۲ ، RAGE