Appraisal of Smart nano drug delivery systems

Background and aims: Over the last decades, smart nano-systems have contributed excessivelyto the progress of drug delivery for medical applications. The smart Nano carriers improve drugbio-distribution and attack diseased cells while protecting healthy tissues. The goal of smart nano-medicines may be broadly defined as the comprehensive monitoring, control, fabrication, restoration,resistance, and advance of all human biological systems, operation from the molecularlevel using engineered devices and nanostructures, and eventually achieving medical benefits.Method: This article highlights recent breakthroughs of smart nano-platforms made of organic(such as polymeric micelles and vesicles, liposomes, dendrimers, and hydrogels) and inorganic(such as quantum dots, gold, and mesoporous silica nanoparticles) substrates in cancer therapies.Results: Smart nano-systems have appeared as potent drug deliveries for cancer treatment due totheir extensive properties of high surface-to-volume ratio with a greater valence for drug loadingand functionalization possibilities. Certainly, the utilization of clinical drugs is often restricteddue to their inherent properties including poor solubility as well as unfavorable pharmacokineticsand bio-distribution. Whereas Smart nano-carriers in order to decrease the side effects and toxicityof chemotherapy drugs can potentially modify the drug solubility and extend the time of bloodcirculation, releasing the medicine in a controlled and sustained approach.Multiple types of nanomaterials like synthetic materials such as liposomes, micelles, dendrimershydrogels, and natural biomaterials such as virus-like nanoparticles, are widely employed assmart drug delivery systems for cancer treatments.Conclusion: Despite the significant developments of recent synthetic approaches, most of allnano-carriers’ function is associated with many undesirable side effects that reduce their efficientoperation in biotechnology and nano-medicine applications. Moreover, since future drug deliverysystems are predicted that use compounds that more efficiently are programmable, and responsiveto biological cues, therefore, the field of smart nano-drug delivery has a bright future. Here, recentadvances in smart nano-carriers in the development of novel platforms for the efficient transportand controlled release of drug molecules have been accentuated.

کلیدواژه ها:

Smart nano-carriers ، Drug delivery ، Cancer therapy