Review of measurement and analysis of biomarkers using inorganic complexes and metal-based nanomaterials

Biomarkers are biochemical/physiological changes in body tissues or fluids that can be accurately and reproducibly measured. They can demonstrate the overall spectrum of the disease and the choice of the type and choosing the type and dosage of drugs can potentially increase the effectiveness and minimize therapeutic interventions. Therefore, the recognition of biomarkers is of particular importance in the development of pharmaceuticals and moving toward personalized medicine. Nanotechnology as a modern scientific field with novel combinations has taken the lead in the fields of medical discernment, imaging, and therapeutic applications. Research of kinds of literature defined that signal generation probes based on inorganic complexes and metal-based nanomaterials can generally be appropriate candidates for diagnosis. Accordingly, in this context, the significance of utilization inorganic chemistry and nanotechnology in terms of identification of biomarkers was highlighted. At the beginning, the principal definitions in this regard were explained. Then, a collection of biomarkers related to a specific disease and several methods for evaluation of biomarkers were described. In the following, the application of inorganic metal complexes and nanoparticles in probes for sensing and imaging was discussed and eventually, current challenges and outlook were offered.

کلیدواژه ها:

Biomarker ، inorganic metal complexes ، inorganic nanoparticles ، imaging modalities ، metal-based signal generation probes ، nanotechnology