Comparing the effects of ropivacaine and lidocaine associated with epinephrine on the heart rate, blood pressure, and amount of bleeding in patients candidate for cleft palate repair: A randomized clinical trial

Background and aims: This study was conducted to compare the effects of two compounds ropivacaine and lidocaine associated with epinephrine on the heart rate, blood pressure, and bleeding rate in children undergoing general anesthesia for the cleft palate repair surgery. Methods: In this study, ۳۰ children candidates for cleft palate surgery who were referred to Mofid Children’s Hospital, affiliated with Shahid Beheshti University of Medical Sciences in ۲۰۲۱, were included by using the convenience sampling method. The patients were randomly divided into two groups. Group ۱ was treated with ropivacaine and group ۲ was treated with lidocaine along with epinephrine. The data were analyzed by the SPSS, version ۲۲. Results: In total, no statistically significant difference was found between the two groups in terms of vital signs of blood pressure and heart rate in the ۱۰ stages studied (P < ۰.۰۵). There was no difference between the two groups in the trend of the changes in blood pressure (P = ۰.۳۸۱) and heart rate (P = ۰.۹۴۰). However, the trend of blood pressure and heart rate had significantly changed during the study in both groups individually (P < ۰.۰۰۱). The bleeding rate (suction) (P < ۰.۰۰۱) and the weight of gases used (P = ۰.۰۰۳) in the second group were significantly higher than in the first group. Conclusion: No difference was found between the effects of ropivacaine and lidocaine combined with epinephrine on the heart rate and blood pressure in patients who were candidates for the cleft palate surgery, but the rate of bleeding (suction) in the second group was more than the first group.

کلیدواژه ها:

Ropivacaine ، Lidocaine ، Epinephrine ، Cleft palate ، Heart rate ، Blood pressure