Improvement of the Wound Healing Process by Janus Nanofibrous Biomimetic Wound Dressings Containing Metal and Metal Oxide Nanoparticles

Since the beginning of time, humans have struggled with closing and healing wounds. Dressings are important in treating wounds, beacuse they prevent infection and speed up the healing process. Most dressings used for wound healing do not simulate the complex extracellular matrix (ECM) and therefore cannot provide a suitable site for wound healing. Biomimetic nanofibers have attracted much attention due to their attractive properties, such as their capacity to deliver bioactive agents, their high surface area, and their enhanced mechanical properties. To increase their capacity for wound healing, nanofibrous materials can be further encapsulated or loaded with metal nanoparticles. Recently, Janus nanofibers have attracted the attention of researchers due to their high surface area to volume ratio, high porosity, and matrix morphology similar to human extracellular matrix. Furthermore, different types of active ingredients can be simultaneously loaded into the Janus structures, and their synergistic effect on the desired functional properties may be inhibited in the Janus structure contacting both sides of its environment. Attempts have been made to investigate the latest biomimetic Janus nanofibrous dressings made with metal and metal oxide nanoparticles and their effect on the wound-healing process.

کلیدواژه ها:

Wound Dressing ، Biomimetic ، Janus Nanofiber ، Nanoparticle