Evaluation of rs۷۹۰۳۱۴۶ Polymorphism in TCF۷L۲ Gene among Type ۲ Diabetes Patients

سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 330

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شناسه ملی سند علمی:

JR_INTJMI-11-4_014

تاریخ نمایه سازی: 16 اردیبهشت 1402

چکیده مقاله:

Background: Diabetes is characterized by decreased insulin sensitivity and is a growing health threat worldwide. Therefore, this study aimed to evaluate the relationship between rs۷۹۰۳۱۴۶ polymorphism in the TCF۷L۲ gene with type ۲ diabetes in East Azerbaijan province, Iran. Materials and method: A total of ۱۰۰ blood samples were collected from diabetic and healthy people. The samples were subjected to specific primers, PCR, and electrophoresis after DNA extraction from all samples and quality control. Finally, the PCR products were treated with RSal restriction enzyme and electrophoresed again, and the target polymorphism was checked. Results: The frequency of genotypes were TT=۳۳.۷%, CC=۱۶.۸% and CT=۴۹.۵% for healthy people and TT=۴۳%, CC=۱۴% and TC=۴۳% in diabetics. The percentage of the T allele in healthy and diabetic people was as much as ۴۲.۱% and ۶۴.۵%, respectively. Conclusion: According to the results, there was probably a relationship between rs۷۹۰۳۱۴۶ polymorphism in the TCF۷L۲ gene and diabetes.

نویسندگان

Salar Momen Maragheh

Biotechnology Research Center (BRC), Pasteur Institute of Iran, Tehran, Iran, Department of Biotechnology, Islamic Azad University, Central Tehran Branch, Tehran, Iran

Alireza Aslani Zakariya

Department of Chemistry, Faculty of Science, Ataturk University, Erzurum, ۲۵۲۴۰, Turkey

Elham Ghaedi

Department of Medicine, Pirogov Russian National Research Medical University, Moscow, Russia

Fahimeh Saeifar

Department of Midwifery, Health Center of Maragheh, Maragheh, East Azerbaijan, Iran, Department of Genetics, Islamic Azad University of Bonab, Bonab, East Azerbaijan, Iran

Mahdi Navid Talemi

Department of Pharmacology, Guilan University of Medical Sciences, Rasht, Guilan, Iran

Mehran Rezanezhad Varjovi

Department of Microbiology, Islamic Azad University of Maragheh, Maragheh, East Azerbaijan, Iran

Mahdi Bagheri

Department of Medicine, Medical University of Ilam, Ilam, Iran

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