Serum and Urine C - Reactive Protein, Mean Platelet Volume and Neutrophil/ Lymphocyte Ratio as Diagnostic Values in Neonatal Sepsis

سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 116

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شناسه ملی سند علمی:

JR_INJPM-11-4_010

تاریخ نمایه سازی: 11 اردیبهشت 1402

چکیده مقاله:

Background: Recently, many research studies with equivocal results, have found Neonatal Sepsis (NS) biomarkers and focused on single regions. Therefore, the aim of this study was to evaluate serum and urine C - Reactive Protein (CRP), Mean Platelet Volume (MPV) and Neutrophil/ Lymphocyte Ratio (NLR) as diagnostic values in NS.Materials and Methods: This case-control study was performed on ۱۴۷ cases (۷۹ overweight or obese children and ۶۸ normal weight children). For evaluating quality of life, the original version of the PedsQL, quality of life questionnaire, was used.Methods: This descriptive-analytical research analyzed Shahid Beheshti Hospital’s probable NS patients. All individuals got a complete blood count, white blood differential, CRP, blood culture, and urine culture. Data was analyzed by SPSS v۲۴.Results: The data indicated that NS infants had substantially higher mean serum levels of MPV (۱۰.۶۳ ± ۱.۰۳ vs. ۸.۶۳ ± ۰.۹۶, P<۰.۰۰۱), NLR (۲.۰۸ ± ۱.۲۴ vs. ۱.۰۱ ± ۰.۵, P<۰.۰۰۱), and CRP (۱۲.۹۷ ± ۵.۰۹ vs ۵.۸۳ ± ۲.۶ and ۹.۶۱ ± ۳.۲۵ vs ۴.۹ ± ۳.۴, P<۰.۰۰۱).The optimum cut-off points for serum and urine CRP, NLR, and MVP were ۱۰, ۶.۷, ۱.۲, and ۹.۵. The highest Area under the Curve (AUC) was detected in MPV (۰.۹۰۹), and the other AUC for serum and urine CRP and NLR were ۰.۸۷۲, ۰.۸۳۱, and ۰.۸۰۴, respectively. Serum CRP had the lowest sensitivity (۷۳.۳%) among urine, NLR, and MPV. Serum CRP had the best specificity, Positive Predictive Value (PPV), and Negative Predictive Value (NPV), identified as ۹۶.۷ %, ۸۸%, and ۹۰%, respectively.Conclusion: Sepsis increases MPV, serum and urine CRP, and NLR in neonates. MPV and serum CRP may detect NS early.

کلیدواژه ها:

C - reactive protein ، ، ، ، ، Mean platelet volume ، ، ، ، ، Neutrophil/ lymphocyte ratio ، ، ، ، ، Neonatal sepsis

نویسندگان

Babak Soltani

Associate professor of pediatrics diseases, Department of Pediatrics, School of Medicine, Infectious Diseases Research Center, Shahid Beheshti Hospital, Kashan University of Medical Sciences

mohammad Reza Sharif

Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran

Ahmad Safari

Department of Pediatrics, School of Medicine, Shahid Beheshti Hospital, Kashan University of Medical Sciences

Mohammad Javad Azadchehr

Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran

MohammadMahdi Heidari

Department of Pediatric, Kashan University of Medical Sciences, Kashan, Iran

Nafiseh Aliabadi

Department of Pediatric , Kashan University of Medical Sciences, Kashan, Iran

Rasoul Etesam por

Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.

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  • Goldstein B, Giroir B, Randolph A. International pediatric sepsis consensus ...
  • Yamey G, Horváth H, Schmidt L, Myers J, Brindis CD. ...
  • Shim GH, Kim SD, Kim HS, Kim ES, Lee HJ, ...
  • Shah BA, Padbury JF. Neonatal sepsis: an old problem with ...
  • Shermadou ES, Mavrogeorgos G Neonatal sepsis. StatPearls. ۲۰۱۸; https://www.ncbi.nlm.nih.gov ...
  • Ng S, Strunk T, Jiang P, Muk T, Sangild PT, ...
  • Simonsen KA, Anderson-Berry AL, Delair SF, Davies HD. Early-onset neonatal ...
  • Shirazi H, Riaz S, Tahir R. Role of the Hematological ...
  • Sakha K, Husseini MB, Seyyedsadri N. The role of the ...
  • Tappero E, Johnson P. Laboratory evaluation of neonatal sepsis. Newborn ...
  • Weyrich AS, Zimmerman GA. Platelets: signaling cells in the immune ...
  • Oh GH, Chung SP, Park YS, Hong JH, Lee HS, ...
  • Wang J, Wang Z, Zhang M, Lou Z, Deng J, ...
  • Djordjevic D, Rondovic G, Surbatovic M, Stanojevic I, Udovicic I, ...
  • Early blood biomarkers to improve sepsis/bacteremia diagnostics in pediatric emergency ...
  • Holub M, Beran O, Kaspříková N, Chalupa P. Neutrophil to ...
  • Ahmed Z, Ghafoor T, Waqar T, Ali S, Aziz S, ...
  • Haque KN. Definitions of bloodstream infection in the newborn. Pediatr ...
  • Shalaby MM, Sobeih AA, Abdulghany WE, Behiry EG, Ismail YM, ...
  • haaban HA, Safwat N. Mean platelet volume in preterm: a ...
  • Rondina MT, Garraud O. Emerging evidence for platelets as immune ...
  • Pattraporn T, Arintaya P, Atikun L, Pothirat C, Chittawatanarat K. ...
  • Yuri Gasparyan A, Ayvazyan LP, Mikhailidis D, Kitas GD. Mean ...
  • Wang J, Wang Z, Zhang M, Lou Z, Deng J, ...
  • Kim CH, Kim SJ, Lee MJ, Kwon YE, Kim YL, ...
  • Mahmood A, Karamat KA, Butt T. Neonatal Sepsis: High antibiotic ...
  • Benitz WE, Han MY, Madan A, Ramachandra P. Serial Serum ...
  • Mathers NJ, Pohlandt F. Diagnostic audit of C - reactive ...
  • Chan Dk, Ho LY. Usefulness of C - reactive protein ...
  • Jave DL, Waites KB. Clinical applications of C - reactive ...
  • Jin Charadze JN, Abelashvili D, McHedlishyili M, Kacharava M. Diagnostic ...
  • Alkan Ozdemir S, Arun Ozer E, Ilhan O, Sutcuoglu S. ...
  • Nugroho ID. Nilai diagnostik neutrophil to lymphocyte count ratio sebagai ...
  • Ruslie RH, Tjipta DG, Samosir CT, Hasibuan BS. Bacterial pattern ...
  • نمایش کامل مراجع