Study of formation of inclusion complex of levamisole with cucurbit[۶]urilusing conductometry thecnique

The interactions between host and guest molecules are normally examined in homogeneous solutions using common experimental techniques to determine the concentration of at least one species. These techniques are: potentiometry, conductometry, spectrophotometry, NMRspectroscopy and calorimetry [۱].Recently it was shown that it is possible to calculate the stability constants of the complexes formedbetween nearly insoluble ligands like dibenzo crown ethers and cations under certain assumptions from the increase in solubility of these ligands in aqueous solutions [۲-۴].The family of cucurbit urils macrocyclic cavitands consisting of several glycoluril fragmentsinterconnected by methylene bridges is interesting due to their unique features [۵-۶], in particular,their ability to have calibrated guests.A cucurbit uril molecule looks like an oblate shaped barrel with portals made of carbonyl groups.The aim of this work is to prepare sample of cucurbit [۶] uril with Levamisole. The stability constant of resulting inclusion complex is calculated.

کلیدواژه ها:

cucurbit [۶]uril ، conductometry ، Levamisole ، inclusion complex