The Effect of Chlamydia trachomatis and mycoplasma Infection on fertility

Introduction: Bacterial infections show good candidates to explain the causes of the idiopathicinfertility among different populations. Infertility is defined as the inability to achieve thepregnancy after one year of regular intercourse. Sexually transmitted diseases (STDs) arecaused by several pathogens, including bacteria and viruses, which can induce the infertilityvia multiple pathophysiological mechanisms. Chlamydia trachomatis and Mycoplasmagenitalium are sexually transmitted bacteria causing urogenital diseases in men and women.Search Method: In the forthcoming systematic review, required data were collected usingkeywords and citing valid databases, such as Scopus, PubMed, Google Scholar and ProQuest.The statistical population includes all studies conducted until ۲۰۲۲ in the field of the effect ofChlamydia trachomatis and mycoplasma Infection on the fertility. After reviewing the relevantfindings and evaluating the quality of the data, ۱۰ articles were analyzed.Results: The diagnosis of genitourinary pathogens was based on the bacterial culture, whichis time-consuming and fails to show adequate sensitivity. Recently, the diagnosis methodsbased on the nucleic acid amplification methods were widely applied in clinics, being feasibleand having relatively high sensitivity and specificity. Moreover, a novel simultaneousamplification testing (SAT) method based on the isothermal amplification of pathogens RNAwas reported to provide accurate and rapid detection of several pathogens.Conclusion: Asymptomatic infections, associated with recurrent and latent infections, aremajor challenges to control the infertility. Increasing awareness among the populations, propersanitation, and proper precaution are the best approaches which can be considered to preventtheir transmission and inhibit their prevalence among people. Understanding the true effects ofthese pathogens and getting more insight into their underlying pathophysiological mechanismswould significantly pave the way to identify the suitable biomarkers and production of newtreatment strategies in the future that would minimize the risks of bacterial infections on malereproductive conception.

کلیدواژه ها:

Mycoplasma ، Chlamydia trachomatis ، fertility