Report of a case of complications caused by the simultaneous use of Sildenafil tablets with Alcohol

سال انتشار: 1401
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 94

نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

CCRMED04_081

تاریخ نمایه سازی: 16 اسفند 1401

چکیده مقاله:

Introduction : Sildenafil Citrate (Viagra) is one of the drugs used in the treatment of erectile dysfunction and increased erection, increasing pulmonary arterial blood pressure and helping to improve blood pressure in people with low blood pressure. This drug was first marketed by Pfizer pharmaceutical company. Sildenafil inhibits phosphodiesterase ۵ (PDE۵), an enzyme that breaks down cGMP, regulating blood flow in the penis. This drug also leads to expansion of blood vessels in the lungs. Sildenafil is taken orally or intravenously. The onset of its effect is usually within ۲۰ minutes and lasts for about ۲ hours. In clinical studies, the most common side effects caused by Sildenafil are headache, flushing, indigestion, nasal congestion, visual disturbances and blurred vision. Its rare but serious side effects include persistent erection (priapism), severe drop in blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden loss of vision.Purpose: The aim of this study was to report of a case of complications caused by the simultaneous use of Sildenafil tablets with Alcohol.Patient introduction: The patient was a ۲۸-year-old boy who was transferred to the emergency room due to sudden loss of consciousness and blindness. Taking a history from the patient's relatives revealed that he had taken sildenafil tablets and then alcohol. In order to find out the reason for the decrease level of consciousness, a CT scan of the brain was immediately requested for the patient. It was found that the patient had extensive cerebral hemorrhage (ich). The bleeding site should be removed. Although the patient underwent surgery, brain hypoxia on the way to the hospital and the rupture of cerebral capillaries due to excessive bleeding and finally serious damage to the brain led to the death of the patient a few hours after the surgery.Discussion and conclusion: As a result, sildenafil in patients who For chest pain or heart problems, nitrate drugs such as Nitroglycerin, Isosorbide Dinitrate, Isosorbide Mononitrate, and some recreational drugs such as "poppers" and alcoholic beverages are prohibited because they lead to a sudden and severe drop in blood pressure.

کلیدواژه ها:

نویسندگان

Mahdieh Sadat Badiee

Ph.D. in Medical Toxicology, Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Ali Vadizadeh

Ph.D. in Medical Toxicology, Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran