Faculty of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz

Introduction :Acetaminophen or Paracetamol is the most common painkiller and antipyretic drug that is used all over the world. The reason for this is the uncomplicated nature of the therapeutic amounts of the drug and the ease of access to it. Due to the aforementioned reasons, since ۱۹۶۶, when the first case of acetaminophen poisoning was reported, the prevalence of poisoning with this drug has increased day by day, so that today it is one of the most common causes of poisoning in the world, and liver failure is caused by poisoning with it. It is among the most common causes of liver transplantation in Europe and America. Alcoholic beverages increase the risk of paracetamol poisoning. Taking more than ۴ grams of acetaminophen per day in the long term causes severe liver failure. Severe blurred vision, blindness, weakness and even liver failure have been reported as side effects of acetaminophen poisoning. Before and after taking this medicine, you should never drink alcohol because it causes irreparable damage to the liver tissue.Purpose:The aim of this study was to report a case of Acetaminophen poisoning with Alcohol consumption.Patient introduction:A ۲۱-year-old woman with symptoms of severe nausea and vomiting and paleness due to the consumption of large amounts of Acetaminophen tablets along with Alcohol in the last ۱۲ hours went to the emergency room. A test to measure the concentration of acetaminophen and alcohol in the blood was requested for the patient, then immediately Stomach lavage was performed and Charcol was prescribed and N-acetyl cysteine was infused and the patient was treated in the intensive care unit. The serum concentration of acetaminophen on the first day was ۶۰۰۰ mg/dL and the serum concentration of alcohol was ۵۵ mg/dL. Two days after the poisoning, the symptoms of the first day were resolved, but abdominal pain and lack of complete urine emptying were observed and liver (ALT and AST) and kidney (ure and Cr) function tests were requested. Liver enzymes were more than ۱۵۰۰ and urea level was ۸۰. and creatinine ۳ was reported, which indicated kidney and liver dysfunction on the second day of poisoning. On the third day, the symptoms of the first day reappeared, and the patient had nausea and vomiting, sweating, paleness, weakness and confusion, and symptoms of jaundice in the skin and The whiteness of the eyes appeared. Unfortunately, the patient died on the fourth day of poisoning due to the late presentation of the patient and the concomitant use of acetaminophen with alcohol and liver failure. Discussion and conclusion:The importance of diagnosing Zords of acetaminophen poisoning is that it is possible to prevent potentially dangerous and fatal complications of this poisoning with quick and appropriate treatment, so acetaminophen poisoning should always be considered in the differential diagnosis of liver failure.

کلیدواژه ها:

Poisoning ، Acetaminophen tablets ، Alcohol