Relationship between LncRNAs and Multiple Sclerosis (MS)
محل انتشار: فصلنامه پزشکی شخصی، دوره: 8، شماره: 28
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 145
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شناسه ملی سند علمی:
JR_PMJ-8-28_003
تاریخ نمایه سازی: 16 اسفند 1401
چکیده مقاله:
Multiple sclerosis (MS), the most common inflammatory demyelinating illness of the central nervous system (CNS), presents a range of clinical symptoms. The body’s immune system attacking myelin causes the transmission block in MS, which increases the electrical capacity of axons. Studies suggest that epigenetic factors play a part in the development of MS. Longer than ۲۰۰ nucleotides in length and widely distributed, lncRNAs are linear RNA transcripts that cannot code for proteins. For instance, evidence suggests that lncRNAs are essential for a number of cellular functions, including immune response regulation, epithelial mesenchymal transition (EMT), cancer cell proliferation and metastasis, cellular homeostasis, and embryonic development. Epigenetic mechanisms have been proven to have a significant impact on the pathophysiology of MS, and their participation has revealed the function of lncRNAs as epigenetic regulatory molecules in molecular processes. The major subjects of this study have been the relationship between lncRNAs and MS, the role of lncRNA in the pathophysiology of the disease, and the diagnostic and prognostic potential of lncRNA in MS.
کلیدواژه ها:
نویسندگان
Reyhaneh Tahouri
Department of Cellular and molecular Biology , Islamic Azad University science and Research Branch.
Ghasem Ghorbani Valezaghard
Department of molecular genetics, Ahar Branch, Islamic Azad University, Ahar, Iran.