Evaluation of MLL۲ (KMT۲B) Gene Expression in Colorectal Cancer Tissue Compared with Adjacent Tumor Free Tissue

Background and Aims: An impairment of expression in MLL۲ gene involved in histone methylation induces alteration in the methylation patterns at enhancers and causes several cancers including colon cancer. In this study, MLL۲ expression was evaluated in North West of Iran. Materials and Methods: To evaluate the MLL۲ expression in patients with colon cancer, ۲۵ tumor samples and ۲۵ samples of tumor margins were collected and analyzed by real-time polymerase chain reaction. Results: KMT۲B level was not associated with age (p=۰.۳), gender (p=۰.۰۵) and tumor size (p=۰.۲) but had relation with stage of tumor (p=۰.۰۴). Conclusions: According to the results obtained from investigating the MLL۲ gene expression, it was found that it has a significant relationship with the stage of tumor.

کلیدواژه ها:

Colorectal cancer ، Histone methylation ، Methylation ، MLL۲ ، colorectal cancer ، MLL۲ gene expression ، methyltransf