IL-۸ May Be the Target of Arsenic in Human Breast Milk

Background and Aims: The critical aim of this study was to evaluate the effects of breast-milk contamination with Nickel and Arsenic, as well as aflatoxin M۱ (AFM۱) on the milk levels of IL-۶ and IL-۸.  Materials and Methods: Breast milk was collected from ۷۶ mothers on the ۳۰th day post-parturition and milk levels of AFM۱, Nickel, Arsenic, IL-۶ and IL-۸ were evaluated. Results: The results showed ۸ and ۲۹ out of ۷۶ collected samples being contaminated with AFM۱, Nickel and Arsenic, respectively. Levels of IL-۶ and IL-۸ in the milk samples did not differ in AFM۱ and Nickel and Arsenic contaminated milk compared with the normal controls (non-contaminated milks). There was a moderate positive relation between milk levels of IL-۸ and Arsenic. Conclusions: Although AFM۱, Nickel and Arsenic are the inducers of cytokine production; they are unable to induce secretion of IL-۶ in breast milk. Arsenic can be a trigger of IL-۸, which is a strong chemoattract for neutrophils. Thus, it appears that Arsenic may induce an inflammation in milk in IL-۸ dependent manner.

کلیدواژه ها:

Aflatoxin M۱ ، Arsenic ، IL-۶ ، IL-۸ ، Nickel