An Adaptive Lyapunov-Based Controller for HIV Treatment

In view of the tremendous importance of patients’ stability in medical sciences‎, ‎this paper addresses the application of a sliding mode control in medical devices‎. ‎In doing so‎, ‎we consider a nonlinear dynamic system that shows the mathematical model of the human immunodeficiency virus‎. ‎This nonlinear model has three variable states‎: ‎healthy cells‎, ‎infected cells‎, ‎and free viruses‎. ‎The proposed controller displays the effect of medication on preventing the production of the virus and blocking the new infection‎. ‎This controller ensures the stability of this dynamic system provided for HIV in the event of a bounded disturbance‎. ‎The stability and convergence of this process are proved by the Lyapunov theorem‎. ‎Finally‎, ‎a numerical example is given to demonstrate the efficiency of the proposed method.

کلیدواژه ها:

HIV‎ ، ‎Mathematical modeling of HIV‎ ، ‎Sliding mode control‎ ، ‎Lyapunov stability