An analysis of the biological activities of organotin (IV) dialylated dithiocarbamate complexes

Significant attention has been given to organotin(IV) dithiocabamate compounds in recent times. This is due to their ability to stabilize specific stereochemistry in their complexes, and their diverse application in agriculture, biology, catalysis and as single source precursors for tin sulfide nanoparticles. These complexes have good coordination chemistry, stability and diverse molecular structures which, thus, prompt their wide range of biological activities. Their unique stereo-electronic properties underline their relevance in the area of medicinal chemistry. Organotin(IV) dithiocabamate compounds owe their functionalities and usefulness to the individual properties of the organotin(IV) and the dithiocarbamate moieties present within the molecule. These individual properties create a synergy of action in the hybrid complex, prompting an enhanced biological activity. The growing interest in the chemistry of sulphur donor ligands are due to their encouraging anticancer, antibacterial and antifungal activities as well as their widespread industrial application. Dithiocarbamates belong to this class and much attention has been paid to them. Novel organotin compounds with the molecular formula RmSn[S۲CN(CH۳)(C۶H۱۱)]۴-m (where m = ۲, R = CH۳, C۲H۵; m = ۳, R = C۶H۵) have been synthesized using in situ method. These compounds were characterized by elemental analysis, IR, ۱H and ۱۳C NMR spectroscopy. Elemental analysis revealed that all compounds were of good purity. Infrared spectra of the compounds showed that the thioureide ν(C-N) band was in the region ۱۴۵۰-۱۵۰۰ cm−۱. The unsplitting band of ν(C-S) in the region ۹۷۴-۹۷۹ cm−۱ indicated the bidentate nature of the chelated dithiocarbamato legends. The ۱۳C NMR chemical shift of the carbon atom in the N-CS۲ group appeared in the range of ۱۹۶.۲۹-۱۹۹.۸۲ ppm. Single crystal analysis from one of these compounds showed that the chelating mode of the dithiocarbamate groups was isobidentate. These compounds have been screened for antibacterial activity against four bacteria; Staphylococcus aureus, Salmonella typhimurium, Pseudomonas aeruginosa and Bacillus subtilis.

کلیدواژه ها:

antibacterial activity ، synthesized compounds ، disc diffusion ، elemental analysis