Increased Risk of Hypertension in Low aged-carriers with rs۲۵۹۶۵۴۲ Risk-allele

Background:Hypertension with its related disorders is one of the most common health problems among the Iranian population. Hypertension can be developed by chronic stress and a positive association between stress and rs۲۵۹۶۵۴۲ has been confirmed. Methods:A Total number of ۱۱۲ hypertensive patients and ۹۷ healthy individuals were involved in the study. Total blood genomic-DNA was extracted and PASA (PCR amplification of specific alleles) method was used to amplify MICA-rs۲۵۹۶۵۴۲ polymorphic site. Different genotypes were visualized. The normality of the data was assessed and the binary logistic regression was used for OR and ۹۵%CI calculations. Results:A-risk allele of rs۲۵۹۶۵۴۲ increased the risk of hypertension development significantly (OR=۱.۷۳۴, p=۰.۰۰۶). Females were significantly more potent to hypertension development than males (OR=۲.۰۱۵, p=۰.۰۱۳). Risk-allele homozygotes (AA) showed a higher risk of hypertension development than GG (OR=۲.۱۳۲, p=۰.۰۲۰) and AG individuals (OR=۳.۲۰۶, p=۰.۰۰۶). Age adjustments at ۷۰ years old, further increased the risk of hypertension development in GG (OR=۳.۷۷۲, p=۰.۰۱۱) and AG (OR=۶.۵۳۱, p=۰.۰۰۹) individuals. Conclusion:A-risk allele of rs۲۵۹۶۵۴۲ could increase the risk of hypertension up to ۳.۲ folds and this risk could be upraised after sex and age adjustments.

کلیدواژه ها:

Hypertension ، rs۲۵۹۶۵۴۲ ، PASA