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مقالات فارسیISIکنفرانسهاژورنالها

Attenuation of Detrimental Effects of Formaldehyde on Sperm Chromatin Quality and Rate of Apoptosis in Mice by Curcumin

محل انتشار: مجله دانشگاه علوم پزشکی کرمان، دوره: 28، شماره: 4
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 117

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لینک ثابت به این مقاله:
https://civilica.com/doc/1582604

شناسه ملی سند علمی:

JR_JKMU-28-4_006

تاریخ نمایه سازی: 19 دی 1401

چکیده مقاله:

Background: The present study aimed to evaluate the sperm chromatin quality and rate of apoptosis in formaldehyde (FA)-exposed mice and the possible protective effects of curcumin (Cur) on the fertility potential of spermatozoa.Methods: Twenty-four adult male NMRI mice were randomly divided into three groups: Group Ι (control), group ΙΙ (Sham) received Cur solvent (۲ ml/day, intraperitoneal), group ΙΙΙ received FA (۱۰ mg/kg, intraperitoneal), and group ΙV received FA+Cur (۱۰۰ mg/kg, intraperitoneal). After ۳۵ days, the spermatozoa from right cauda epididymis were analyzed using Chromomycin A۳ (CMA۳) and TUNEL staining.Result: Regarding CMA۳ and TUNEL tests, the data revealed a significant increase (p <۰.۰۵) in control and sham groups compared to the FA and FA+Cur groups. There was also a significant decrease in CMA۳ tests and apoptosis in FA+Cur group compared to FA group (p <۰.۰۵).Conclusion: Cur, as a potent antioxidant, can attenuate detrimental effects of FA on the chromatin quality and apoptosis in an experimental animal model.

کلیدواژه ها:

Formaldehyde ، curcumin ، Chromatin quality ، Apoptosis ، Sperm ، Mice

نویسندگان

Abbas Shahedi

Department of Biology and Anatomical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Morteza Anvari

Department of Biology and Anatomical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Reproductive Biology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd,

Aghdas Mirjalili

Department of Biology and Anatomical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Majid Pourentezari

Department of Biology and Anatomical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

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