Enhanced Corneal Permeation of Pilocarpine Using Liposome Technology
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 99
فایل این مقاله در 9 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_JKMU-28-5_005
تاریخ نمایه سازی: 19 دی 1401
چکیده مقاله:
Background: A novel liposomal pilocarpine formulation as an ophthalmic drug delivery system has been designed to treat patients with glaucoma. The purpose of the present study was to formulate and evaluate liposomes loaded with pilocarpine and to evaluate permeation through rabbit cornea.Method: Liposomes containing pilocarpine were prepared using thin film method. The quantities of soya lecithin and cholesterol were changed to enhance the encapsulation of the drug. The physicochemical properties of the prepared liposomes were evaluated according to their viscosity, pH, particle size, in vitro drug release, and transcorneal rabbit permeation. Dialysis membrane method was utilized to assess drug release profile.Results: The results indicated that the mean particle sizes of liposomes were ۱۲۰.۵-۲۱۲ nm and the pH and viscosity of formulations were in the range of ۶.۳۰-۶.۶۳ and ۴۳.۸۵-۸۰.۱ cps, respectively. According to the release study results, maximumally ۶۰% of the drug released from liposomal formulations after ۲۴ hours of the experiment. Also, the cumulative percentage of the drug permeated through rabbit cornea was differing from ۳.۸۶ to ۱۴.۹%. Irrespective from the composition and characteristics of the different liposomal formulations, they significantly increased the drug partitioning, permeability coefficient and flux of pilocarpine in rabbit cornea ex vivo model in comparison to control drug solution.Conclusion: The present study proved that any alteration in composition and nature of pilocarpine liposomal formulations may affect the drug permeability parameters through corneal membrane and also physico-chemical properties. It is probably due to the change in corneal structure in the presence of different liposomes composition.
کلیدواژه ها:
نویسندگان
Eskandar Moghimipour
Nanotechnology Research Center,Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Sahar Farrokhi
Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Anayatollh Salimi
Nanotechnology Research Center,Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :