Salvia sahendica, phytochemical investigation and pharmacological activities

Introduction: Salvia sahendica is a fragrant and perennial plant of the mint family that grows widely in the northwest of Iran. Terpenoids (including diterpene, norditerpene, triterpene, sesterpene and norsterpene) and flavonoids are the main compounds of this plant.Method: After using the main databases, ۲۱ articles were selected as main data.Purpose: The purpose of writing this review article was to find all the compounds in this plant and classify them in the first step, and to specify all the biological properties of this plant in the next step, which is summarized.Discussion and conclusion: Different compounds of Sahandi sage have been identified. During the extracted studies mentioned in the article, we found ۴ flavonoids, ۲ terpenoids, ۲ estradiols, ۵ sesterpenes, ۳ norditerpenes, ۱۲ diterpenes, and ۴ triterpenes. Triterpenes such as oleanolic acid, betulinic acid and ursolic acid have activities such as anti-ulcer and stomach protector. By binding to benzodiazepine receptors, flavonoids can play a role in controlling seizures as well as relieving anxiety and drowsiness. New studies indicate the antimicrobial effects of norditerpenes against some bacteria such as B.cereus and S.aureus. New findings show that four diterpenoids of the abitan type, which include (sehendol, sehendone, ۱۲-deoxy-salupisone and sehendinone) have significant cytotoxicity against human cervical cancer (HeLa) and colorectal adenocarcinoma (Caco-۲). The n-hexane extract of Sahandi sage root inhibits the growth of Plasmodium falciparum K۱ strain. Eight compounds isolated from sage plant, which include (۱۲-deoxy-salupisone, sahandinone, ۱۲-deoxy-۶, ۷-dehydrovilinone, Δ-۹ ferroginol, ferroginol, ۷-alpha-acetoxyrilinone, sahandol and sahandon) have biological effects in Equal to T. brucei rhodesiense STIB ۹۰۰, P. falciparum K۱ properties and cytotoxicity in rat myoblast (L۶) cells.

کلیدواژه ها:

Salvia sahendica ، phytochemical study ، biological activities (properties) ، terpenes ، antioxidant