Association Between HOTAIR rs۹۲۰۷۷۸ and H۱۹ rs۳۷۴۱۲۱۹ Polymorphisms with Hashimoto’s Thyroiditis (HT) and Graves’ Disease (GD)

Background: Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) are two autoimmune thyroid diseases (AITDs). The current study aimed to assess possible association between HOTAIR rs۹۲۰۷۷۸ and H۱۹ rs۳۷۴۱۲۱۹ polymorphisms with GD and HT.   Methods: We recruited ۲۴۸ patients with autoimmune thyroid disease (۱۳۳ HT patients and ۱۱۵ GD patients) and ۱۳۵ age- and sex-matched controls. The PCR-RFLP method was applied for genotyping of HOTAIR rs۹۲۰۷۷۸, and H۱۹ rs۳۷۴۱۲۱۹ polymorphisms.   Results: The HOTAIR rs۹۲۰۷۷۸ GA frequency was significantly higher in control compared to HT group. The Overdominant model showed a significant association with the risk of HT. However, no significant association was observed between this polymorphism and HT susceptibility in dominant and recessive models. The H۱۹ rs۳۷۴۱۲۱۹ GA was more repeated in HT patients compared to control group, but the difference was not significant. There was no association between HOTAIR rs۹۲۰۷۷۸ and H۱۹ rs۳۷۴۱۲۱۹ polymorphisms with GD in all genetic models.   Conclusions:Our findings indicated that HOTAIR rs۹۲۰۷۷۸ polymorphism decreased the risk of HT. Since, this the first study, further studies with different races are required to confirm our results.

کلیدواژه ها:

Hashimoto’s thyroiditis ، Graves’ disease ، HOTAIR ، H۱۹ ، Polymorphism