Paternal Balanced Reciprocal Translocation, ۴۶ XY,t (۶:۱۳) (p۲۲.۲; q۱۱.۱) Resulted in Blighted Ovum followingAssis ted Reproductive Technique

Background: Infertility is an important problem involving a lotof couples in the world. One of causes of infertility can be chromosomalrearrangements such as translocations. In this s tudy,we explained the outcome of intra-cytoplasmic sperm injection(ICSI) cycle of an infertile couple with translocation.Materials and Methods: A couple with his tory of ۳ years’ infertilityreferred to our infertility clinic. Semen quality of thehusband was normal according to WHO ۲۰۲۱. The couple hada his tory of one failed intra uterine insemination (IUI) and alsoone failed ICSI cycle. After evaluation of laboratories tes ts andphysical examination, the couple referred to genetic center forkaryotyping. The wife showed normal karyotype, although thehusband presented balanced reciprocal translocation betweenshort arm of chromosome ۶ and long arm of chromosome ۱۳[۴۶ XY, t (۶:۱۳) (p۲۲.۲; q۱۱.۱)]. While couple was consulted todo PGD/ICSI cycle, they persis t on ICSI cycle only. Followinghormonal s timulation, ۶ oocytes retrieved following flushing.After sperm injection, fertilized oocytes were cultured for ۳days. ۴ good quality embryos were frozen. ۲ days before embryotransfer, thawing was performed and embryos were culturedfor ۲ other days.Results: ۲ embryos arrived to blas tocys t s tage (۱ expanded and۱ early) and transferred. After ۱۴ days, β-hCG was evaluated andshowed positive result. Sonographic evaluation in sixth week followingembryo transfer showed an empty ges tational sac.Conclusion: Paternal balanced reciprocal translocation, ۴۶ XY,t (۶:۱۳) (p۲۲.۲; q۱۱.۱) resulted in blighted ovum following ICSIcycle.

کلیدواژه ها:

Blighted Ovum ، Chromosomal Rearrangements ، Infertility ، Karyotype ، Translocation