Reaction and Identification of N-Saccharinylketene in the -lactam Synthesis by stable free radical TEMPO

New trans-β-lactams have been stereoselectively synthesized by reaction of Nsaccharinylaceticacid and aromatic imines with Mukaiyama’s reagent. Our approach to these valuableheterocyclic scaffolds involves a formal [ π+ π] cycloaddition between aromatic imines and the Nsaccharinylketeneas a novel ketene which was generated in situ. The identification of the ketene wasconfirmed by reaction with the stable free radical TEMPO.

کلیدواژه ها:

TEMPO ، N-Succharinylketene ، β-Lactam ، [۲ π+۲ π] Cycloaddition